Mohammad R. Seyedsayamdost – Princeton University Department of Chemistry

Kayrouz, C. M.; Huang, J.; Hauser, N.; Seyedsayamdost, M. R. Biosynthesis of Selenium-Containing Small Molecules in Diverse Microorganisms. Nature 2022, 610, 199–204.

Clark, K. A.; Covington, B. C.; Seyedsayamdost, M. R. Biosynthesis-Guided Discovery Reveals Enteropeptins as Alternative Sactipeptides Containing N-Methylornithine. Nat. Chem. 2022, 14, 1390–1398.

Bushin, L. B.; Covington, B. C.; Clark, K. A.; Caruso, A.; Seyedsayamdost, M. R. Bicyclostreptins are Radical SAM Enzyme-modified Peptides with Unique Cyclization Motifs. Nat. Chem. Biol. 2022, I18, 1135–1143.

Covington, B. C.; Seyedsayamdost, M. R. Vitamin B3 Triggers Biosynthesis of Secondary Metabolite Dormancy Signals in Streptococcus suis. J. Am. Chem. Soc. 2022, 144, 14997–15001.

Li, A.; Okada, B. K.; Rosen, P. C.; Seyedsayamdost, M. R. Piperacillin Triggers Virulence Factor Biosynthesis via the Oxidative Stress Response in Burkholderia thailandensis. Proc. Natl. Acad. Sci. USA 2021, 118, e2021483118.

Covington, B. C.; Xu, F.; Seyedsayamdost, M. R. A Natural Product Chemist’s Guide to Unlocking Silent Biosynthetic Gene Clusters. Annu. Rev. Biochem. 2021, 90, 763–788.

Bushin, L. B.; Covington, B. C.; Rued, B. E.; Federle, M. J.; Seyedsayamdost, M. R. Discovery and Biosynthesis of Streptosactin, a Sactipeptide with an Alternative Topology Encoded by Commensal Bacteria in the Human Microbiome. J. Am. Chem. Soc. 2020, 142, 16265–16275.

Forneris, C.C.*; Nguy, A. K. L.*; Seyedsayamdost, M. R. Mapping and Exploiting the Promiscuity of OxyB toward Biocatalytic Production of Vancomycin Aglycone Variants. ACS Catal. 2020, 10, 9287–9298.

Caruso, A.; Martinie, R. J.; Bushin, L. B.; Seyedsayamdost, M. R. Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical SAM Enzymes. J. Am. Chem. Soc. 2019, 141, 16610–16614.

Moon, K.; Xu, F.; Seyedsayamdost, M. R. Cebulantin, A Cryptic Lanthipeptide Antibiotic Uncovered via Bioactivity-Coupled HiTES. Angew. Chem. Int. Ed. 2019, 58, 5973–5977.

Xu, F.; Wu, Y.; Zhang, C.; Davis, K. M.; Moon, K.; Bushin, L. B.; Seyedsayamdost, M. R. A Genetics-Free Method for High-Throughput Discovery of Cryptic Microbial Metabolites. Nat. Chem. Biol. 2019, 15, 161–168.

Forneris, C. C.; Seyedsayamdost, M. R. In Vitro Reconstitution of OxyC Activity Enables Total Chemo-Enzymatic Syntheses of Vancomycin Aglycone Variants. Angew. Chem. Int. Ed. 2018, 57, 8048–8052.

Seyedsayamdost, M. R., “High-throughput platform for the discovery of elicitors of silent bacterial gene clusters.” Proceedings of the National Academy of Sciences of the United States of America 2014, 111 (20), 7266-7271.

Seyedsayamdost, M. R.; Cleto, S.; Carr, G.; Vlamakis, H.; Vieira, M. J.; Kolter, R.; Clardy, J., “Mixing and Matching Siderophore Clusters: Structure and Biosynthesis of Serratiochelins from Serratia sp. V4.” Journal of the American Chemical Society 2012, 134 (33), 13550-13553.

Traxler, M. F.; Seyedsayamdost, M. R.; Clardy, J.; Kolter, R., “Interspecies modulation of bacterial development through iron competition and siderophore piracy.” Molecular Microbiology 2012, 86 (3), 628-644.

Adler, C.; Corbalan, N. S.; Seyedsayamdost, M. R.; Pomares, M. F.; de Cristobal, R. E.; Clardy, J.; Kolter, R.; Vincent, P. A., “Catecholate Siderophores Protect Bacteria from Pyochelin Toxicity.” Plos One 2012, 7 (10).

Chandler, J. R.; Truong, T. T.; Silva, P. M.; Seyedsayamdost, M. R.; Carr, G.; Radey, M.; Jacobs, M. A.; Sims, E. H.; Clardy, J.; Greenberg, E. P., “Bactobolin Resistance Is Conferred by Mutations in the L2 Ribosomal Protein.” Mbio 2012, 3 (6).

Seyedsayamdost, M. R.; Carr, G.; Kolter, R.; Clardy, J., “Roseobacticides: Small Molecule Modulators of an Algal-Bacterial Symbiosis.” Journal of the American Chemical Society 2011, 133 (45), 18343-18349.

Seyedsayamdost, M. R.; Traxler, M. F.; Zheng, S.-L.; Kolter, R.; Clardy, J., “Structure and Biosynthesis of Amychelin, an Unusual Mixed-Ligand Siderophore from Amycolatopsis sp. AA4.” Journal of the American Chemical Society 2011, 133 (30), 11434-11437.

Minnihan, E. C.; Seyedsayamdost, M. R.; Uhlin, U.; Stubbe, J., “Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine-Substituted Escherichia coli Ribonucleotide Reductases.” Journal of the American Chemical Society 2011, 133 (24), 9430-9440.

Seyedsayamdost, M. R.; Yee, C. S.; Stubbe, J., “Use of 2,3,5-F3Y-beta 2 and 3-NH2Y-alpha 2 To Study Proton-Coupled Electron Transfer in Escherichia coli Ribonucleotide Reductase.” Biochemistry 2011, 50 (8), 1403-1411.

Carr, G.; Seyedsayamdost, M. R.; Chandler, J. R.; Greenberg, E. P.; Clardy, J., “Sources of Diversity in Bactobolin Biosynthesis by Burkholderia thailandensis E264.” Organic Letters 2011, 13 (12), 3048-3051.

Fernandes, N.; Case, R. J.; Longford, S. R.; Seyedsayamdost, M. R.; Steinberg, P. D.; Kjelleberg, S.; Thomas, T., “Genomes and Virulence Factors of Novel Bacterial Pathogens Causing Bleaching Disease in the Marine Red Alga Delisea pulchra.” Plos One 2011, 6 (12).

Seyedsayamdost, M. R.; Case, R. J.; Kolter, R.; Clardy, J., “The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis.” Nature Chemistry 2011, 3 (4), 331-335.

Seyedsayamdost, M. R.; Chandler, J. R.; Blodgett, J. A. V.; Lima, P. S.; Duerkop, B. A.; Oinuma, K.-I.; Greenberg, E. P.; Clardy, J., “Quorum-Sensing-Regulated Bactobolin Production by Burkholderia thailandensis E264.” Organic Letters 2010, 12 (4), 716-719.

Seyedsayamdost, M. R.; Argirevic, T.; Minnihan, E. C.; Stubbe, J.; Bennati, M., “Structural Examination of the Transient 3-Aminotyrosyl Radical on the PCET Pathway of E. coli Ribonucleotide Reductase by Multifrequency EPR Spectroscopy.” Journal of the American Chemical Society 2009, 131 (43), 15729-15738.

Offenbacher, A. R.; Vassiliev, I. R.; Seyedsayamdost, M. R.; Stubbe, J.; Barry, B. A., “Redox-Linked Structural Changes in Ribonucleotide Reductase.” Journal of the American Chemical Society 2009, 131 (22), 7496-+.

Minnihan, E. C.; Seyedsayamdost, M. R.; Stubbe, J., “Use of 3-Aminotyrosine To Examine the Pathway Dependence of Radical Propagation in Escherichia coli Ribonucleotide Reductase.” Biochemistry 2009, 48 (51), 12125-12132.

Reece, S. Y.; Lutterman, D. A.; Seyedsayamdost, M. R.; Stubbe, J.; Nocera, D. G., “Re(bpy)(CO)(3)CN as a Probe of Conformational Flexibility in a Photochemical Ribonucleotide Reductase.” Biochemistry 2009, 48 (25), 5832-5838.

Reece, S. Y.; Seyedsayamdost, M. R.; Stubbe, J.; Nocera, D. G., “Direct observation of a transient tyrosine radical competent for initiating turnover in a photochemical ribonucleotide reductase.” Journal of the American Chemical Society 2007, 129 (45), 13828-+.

Seyedsayamdost, M. R.; Chan, C. T. Y.; Mugnaini, V.; Stubbe, J.; Bennati, M., “PELDOR spectroscopy with DOPA-beta 2 and NH2Y-alpha 2s: Distance measurements between residues involved in the radical propagation pathway of E-coli ribonucleotide reductase.” Journal of the American Chemical Society 2007, 129 (51), 15748-+.

Seyedsayamdost, M. R.; Xie, J.; Chan, C. T. Y.; Schultz, P. G.; Stubbe, J., “Site-specific insertion of 3-aminotyrosine into subunit alpha 2 of E-coli ribonucleotide reductase: Direct evidence for involvement of Y-730 and Y-731 in radical propagation.” Journal of the American Chemical Society 2007, 129 (48), 15060-15071.

Reece, S. Y.; Seyedsayamdost, M. R.; Stubbe, J.; Nocera, D. G., “Photoactive peptides for light-initiated tyrosyl radical generation and transport into ribonucleotide reductase.” Journal of the American Chemical Society 2007, 129 (27), 8500-8509.

Seyedsayamdost, M. R.; Stubbe, J., “Forward and reverse electron transfer with the Y(356)DOPA-beta 2 heterodimer of E-coli ribonucleotide reductase.” Journal of the American Chemical Society 2007, 129 (8), 2226-+.

Seyedsayamdost, M. R.; Yee, C. S.; Stubbe, J., “Site-specific incorporation of fluorotyrosines into the R2 subunit of E-coli ribonucleotide reductase by expressed protein ligation.” Nature Protocols 2007, 2 (5), 1225-1235.

Reece, S. Y.; Seyedsayamdost, M. R.; Stubbe, J.; Nocera, D. G., “Electron transfer reactions of fluorotyrosyl radicals.” Journal of the American Chemical Society 2006, 128 (42), 13654-13655.

Seyedsayamdost, M. R.; Stubbe, J., “Site-specific replacement of Y-356 with 3,4-dihydroxyphenylalanine in the beta 2 subunit of E. coli ribonucleotide reductase.” Journal of the American Chemical Society 2006, 128 (8), 2522-2523.